Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA |
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| Authors: | Park Myunji Bruice Thomas C |
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| Institution: | Department of Chemistry and Biochemistry, University of Califonia at Santa Barbara, CA 93106, USA. |
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| Abstract: | The melting properties of hexameric oligonucleotide AgTgAgTgAgT, in which the phosphodiester linkages of the DNA have been replaced by guanidium linkages, have been evaluated. Using the juvenile esterase gene as a target, the binding of a 20-mer DNG/DNA chimera that includes AgTgAgTgAgT is more than 10(5.7) stronger than the binding of 20-mer composed solely of DNA. |
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