Three CA/GT repeat polymorphisms from loci D21S414 and D21S1234 on human chromosome 21 |
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| Authors: | Assumpció Bosch Stefan Wiemann Wilhelm Ansorge David Patterson Xavier Estivill |
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| Affiliation: | (1) Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, L'Hospitalet de Llobregat, E-08907 Barcelona, Catalunya, Spain;(2) EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany;(3) Eleanor Roosevelt Institute, 1899 Gaylord Street, 80206 Denver, CO, USA |
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| Abstract: | We report three new polymorphic CA repeat microsatellites (ABM-21, ABM-C37A, and ABM-C37B) in two different loci (D21S414 and D21S1234), located in bands q21 and q11.2 of human chromosome 21 (HC21) and that were isolated from a HC21 phage library (LA21NS01). Heterozygosities for ABM-21, ABM-C37A, and ABM-C37B were 0.74, 0.50, and 0.67 respectively. These three CA repeat markers should be useful in the construction of a high resolution genetic map of this region of HC21. |
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