Antibacterial and immunomodulatory activities of bovine lactoferrin against <Emphasis Type="Italic">Escherichia coli</Emphasis> O157:H7 infections in cattle |
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| Authors: | Evelien Kieckens Joanna Rybarczyk Eric Cox Daisy Vanrompay |
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| Institution: | 1.Laboratory of Immunology and Animal Biotechnology, Department of Animal Production, Faculty of Bioscience Engineering,Ghent University,Ghent,Belgium;2.Laboratory of Immunology, Faculty of Veterinary Medicine,Ghent University,Merelbeke,Belgium |
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| Abstract: | Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a zoonotic pathogen that causes food-borne disease in humans ranging from watery diarrhea to bloody diarrhea and severe hemorrhagic colitis, renal failure and hemolytic uremic syndrome. Cattle, the most important source of E. coli O157:H7 transmission to humans, harbor the bacteria in their gastrointestinal tract without showing clinical symptoms. Prevention of E. coli O157:H7 infections in ruminants could diminish the public health risk. However, there is no specific treatment available nor a vaccine or a therapeutic agent which completely prevents E. coli O157:H7 infections in cattle. This paper provides an overview of latest research data on eradicating enterohemorrhagic E. coli O157:H7 in ruminants by use of bovine lactoferrin administration. The article provides insights into the anti-microbial and immunomodulatory activities of bovine lactoferrin against E. coli O157:H7 infections in cattle. |
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