BIOSYNTHESIS OF ASPARTIC, GLUTAMIC, γ-AMINO-BUTYRIC ACIDS AND GLUTAMINE IN BRAIN OF RATS DEPRIVED OF TOTAL SLEEP OR OF PARADOXICAL SLEEP |
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| Authors: | J Mark Y Godin P Mandel |
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| Institution: | Centre de Neurochimie du CNRS, Institut de Chimie Biologique, Facultéde Médecine, 67 Strasbourg, France |
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| Abstract: | Abstract— The 14C]glucose incorporation rate into brain aspartate, glutamate, GABA and glutamine in rats deprived of total and paradoxical sleep was studied. The specific radioactivities of the isolated metabolites were related to the specific radioactivity of brain glucose. It was expected that the incorporation of radioactivity would reflect subtle changes occurring in brain amino acid metabolism during total and selective paradoxical sleep deprivation. The results show an increased specific radioactivity of glutamine in total sleep-deprived rats. The variation in specific radioactivity of glutamine without a change in its concentration indicates an increased turnover of this compound. The reasons and possible mechanism for the change in glutamine specific radioactivity are discussed. |
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