| 子宫肌瘤大鼠模型的病理改变及病因分析 |
| |
| 引用本文： | 奚剑敏,丁正香.子宫肌瘤大鼠模型的病理改变及病因分析[J].现代生物医学进展,2010,10(3). |
| |
| 作者姓名： | 奚剑敏 丁正香 |
| |
| 作者单位： | 湖南省中医药研究院附属医院病理科,湖南,410006 |
| |
| 摘 要： | 目的:观测子宫肌瘤大鼠模型的病理改变来探讨子宫肌瘤的病因机制。方法:将20只大鼠随机分为2组:正常对照组、模型组。采用雌、孕激素负荷法建立大鼠子宫肌瘤模型,观察大鼠子宫大体形态;HE染色镜下观察大鼠子宫平滑肌病理改变;镜下测量子宫平滑肌厚度,运用免疫组织化学检测方法来观察雌激素和孕激素在局部平滑肌的反应。结果:雌、孕激素负荷造模后,大鼠子宫大体观子宫色泽晦暗,明显肿胀、结节;镜下观察大鼠子宫平滑肌增生,细胞排列紊乱;平滑肌增厚,部分呈瘤样增生。两组局部ER、PR检测存在显著差异。结论:镜下观察大鼠模型组的子宫有平滑肌瘤形成,雌、孕激素负荷法大鼠子宫肌瘤模型成功建立。子宫平滑肌瘤形成的病因机制中,雌、孕激素起重要作用,而且跟局部平滑肌对雌、孕激素的敏感性密切相关。
|
| 关 键 词： | 雌、孕激素 子宫肌瘤 动物模型 病因机制 |
Pathological Changes in the Model of Hysteromyoma in Rat and Etiological Factor Analysis |
| |
| Xi Jianmin,Ding Zhengxiang.Pathological Changes in the Model of Hysteromyoma in Rat and Etiological Factor Analysis[J].Progress in Modern Biomedicine,2010,10(3). |
| |
| Authors: | Xi Jianmin Ding Zhengxiang |
| |
| Institution: | Xi Jianmin & Ding Zhengxiang (Pathology Department of the Affiliated Hospital of Hunan Academy of TCM 410006) |
| |
| Abstract: | Objective:To probe into the etiological mechanism of hysteromyoma by observing pathological changes in the model of hysteromyoma in rat.Methods:Divide 20 rats into two groups at random: a normal matched group and a model group. Create the model of hysteromyoma in rat by critical loads approach of estrogen and progestational hormone. Observe the gross morphological features of the hystera. Observe the pathological changes of the uterine smooth muscle of the rat with the HE microscope. Measure the thickness o... |
| |
| Keywords: | estrogen progestational hormone hysteromyoma animal model etiological mechanism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
