Mucosal and systemic antibody responses in humans infected with simian foamy virus |
| |
| Authors: | Cummins James E Boneva Roumiana S Switzer William M Christensen Logan L Sandstrom Paul Heneine Walid Chapman Louisa E Dezzutti Charlene S |
| |
| Institution: | HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cummins@sri.org |
| |
| Abstract: | Simian foamy virus (SFV) infection and the subsequent immune response are not well characterized. Blood plasma, saliva, and urine were obtained from four humans and nine chimpanzees persistently infected with chimpanzee-type SFV for an unknown length of time. SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees. Overall, chimpanzee samples had higher anti-SFV IgG titers than humans. These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
