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Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes |
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| Authors: | Sandip Paul Sumit K Bag Sabyasachi Das Eric T Harvill Chitra Dutta |
| Affiliation: | (1) Bioinformatics Center, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata, 700 032, India;(2) Department of Biology, The Pennsylvania State University, Mueller Lab, University Park, PA 16802, USA;(3) Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA;(4) Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Kolkata, 700 032, India |
| Abstract: | BackgroundHalophilic prokaryotes are adapted to thrive in extreme conditions of salinity. Identification and analysis of distinct macromolecular characteristics of halophiles provide insight into the factors responsible for their adaptation to high-salt environments. The current report presents an extensive and systematic comparative analysis of genome and proteome composition of halophilic and non-halophilic microorganisms, with a view to identify such macromolecular signatures of haloadaptation. |
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