| 1988年上海甲型肝炎暴发流行中从毛蚶分离到甲型肝炎病毒 |
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| 引用本文： | 焦永真,陈美征.1988年上海甲型肝炎暴发流行中从毛蚶分离到甲型肝炎病毒[J].病毒学报,1990,6(4):312-315. |
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| 作者姓名： | 焦永真 陈美征 |
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| 作者单位： | 卫生部上海生物制品研究所
(焦永真,韩剑秋,王宪明,刘晶,刁武萍,杨菲茹,王菊萍),黑龙江省卫生防疫站
(陈美征,王勇),江苏省南通市传染病院(刘求) |
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| 摘 要： |
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| 关 键 词： | 甲型肝炎病毒 毛蚶 |
ISOLATION OF HEPATITIS A VIRUS FROM CLAMS DURING A SEVERE OUTBREAK OF HEPATITIS A IN SHANGHAI, 1988 |
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| Jiao Yongzhen Han Jianqiu Wang Xianming Liu JingDiao VVuping Yang Feiru Wang JupingChen Meizheng Wang Yong Liu Qiu.ISOLATION OF HEPATITIS A VIRUS FROM CLAMS DURING A SEVERE OUTBREAK OF HEPATITIS A IN SHANGHAI, 1988[J].Chinese Journal of Virology,1990,6(4):312-315. |
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| Authors: | Jiao Yongzhen Han Jianqiu Wang Xianming Liu JingDiao VVuping Yang Feiru Wang JupingChen Meizheng Wang Yong Liu Qiu |
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| Institution: | Jiao Yongzhen Han Jianqiu Wang Xianming Liu JingDiao VVuping Yang Feiru Wang JupingChen Meizheng Wang Yong Liu Qiu Shanghai Institute of Biological ProductsSanitation and Epidemic Prevention Station of Heilongjiang Province Nantong Infectious Disease Hospital. |
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| Abstract: | Epideiniological investigation proved the cause of viral hepatitis A outbreak in Shanghai was due to the eating of raw clams ( Area subcrensta Lisckke ) which were collected from Qidong, Jiangsu Province, 1988. The results of etiological study showed that both "full" and "empty" hepatitis A virus particle clusters were found by immune electron microscope in clam extracts collected from Qidong, in addition,Rota virus-like and coro-navirus-like particles, as well as different forms of bacteria could also be observed. Three strains of hepatitis A virus were isolated in Frhk4 and human diploid lung fibroblast ( HDLF ) 2BS and KMB17 cell cultures, and two of them were identified by immunofluorescent blocking test, neutrali-zation test and immuno-electron microscope examination. Both strains were further proved to be hepatitis A virus.The newly isolated hepatitis A virus has been stably passed in HDLF cells with titers of 7.0 to 9.0 TCID50/ml. These resuhs demonstrated that clams were contaminated by hepatitis A virus from their living enviro-me nt. |
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| Keywords: | Clam Hepatitis A virus |
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