Growth inhibition of clonal osteosarcoma cell-lines by low concentrations of glucocorticoid hormones |
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Authors: | Y Eilam M Silbermann N Szydel |
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Affiliation: | 1. The Institute of Microbiology, The Hebrew University - Hadassah Medical School, Jerusalem, Israel;2. Ichilov Hospital, Tel Aviv, Israel;3. Technion School of Medicine, Haifa, Israel |
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Abstract: | Clonal osteosarcoma cell line, ROS , showed marked inhibition of [3H]thymidine incorporation in response to low concentrations (10?10 M) of triamcinolone acetonide and dexamethasone. Hydrocortisone and corticosterone induced inhibition at somewhat higher concentrations. The osteosarcoma cell line ROS responded similarly to triamcinolone acetonide and dexamethasone but at higher concentrations of the hormones. In ROS the inhibitory effects of triamcinolone acetonide were accompanied by only slight elevation in the amount of intracellular exchangeable Ca2+. In contrast, in primary cultures of normal rat-calvarian bone cells, [3H]thymidine incorporation was inhibited to a much lesser extent only at higher concentrations of triamcinolone acetonide (10?7 M). The difference in the susceptibility of normal and malignant bone cells to the inhibitory effects of glucocorticoids may have potential therapeutic importance. |
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Keywords: | TA triamcinolone acetonide Saline Hepes |
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