A new indole alkaloid and anti-inflammatory constituents from Strychnos cathayensis |
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| Authors: | Chen Jih-Jung Luo Yu-Ting Hwang Tsong-Long Sung Ping-Jyun Wang Tai-Chi Chen Ih-Sheng |
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| Affiliation: | Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw |
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| Abstract: | A new indole alkaloid, 11,12-dimethoxyhenningsamine, was isolated from the roots of Strychnos cathayensis, together with 19 known compounds. The structure of this new compound was determined through spectroscopic and mass-spectrometric analyses. Among the isolated compounds, 11-methoxyhenningsamine and aesculetin dimethyl ether exhibited potent inhibition (IC(50) < 5.5 microg/ml) on superoxide-anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B. |
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| Keywords: | Strychnos cathayensis Indole alkaloids Alkaloids Henningsamine, 11,12‐dimethoxy‐ Anti‐inflammatory activity |
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