Highly stereoselective synthesis of (2'R)-[2'-2H]-deoxyribonucleosides and synthesis of their oligonucleotides. |
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| Authors: | E Kawashima T Sekine M Miyahara Y Aoyama I Hirao M Kainosho Y Kyogoku Y Ishido |
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| Institution: | Laboratory of Pharmaceutical Chemistry, Tokyo College of Pharmacy, Japan. |
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| Abstract: | Highly stereoselective synthesis of (2'R)-2'-2H]-2'-deoxyribonucleosides (2'R:2'S = > 99:1) were accomplished by treating 2'-bromo-3',5'-O-TPDS-2'-deoxyribonucleosides with tributyltin deuteride at lower temperatures such as -60 degrees C in the presence of triethylborane. Moreover, synthesis of some oligodeoxyribonucleosides involving them will be described. |
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