In vitro effects of 4-hydroperoxycyclophosphamide on concanavalin A-induced human suppressor T cells |
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Authors: | Abraham Klajman Ilana Drucker Yosef Manor Shlomo Ben-Efraim |
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Affiliation: | (1) Laboratory for Clinical Immunology and Medical Department, Meir Hospital, Kfar-Saba, Israel;(2) Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, 69978 Tel-Aviv, Israel |
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Abstract: | Summary Treatment in vitro of human peripheral blood lymphocytes (PBL) with ConA induced the generation of suppressor cells which inhibited T cell blastogenic response to ConA and of allogeneic response in the mixed lymphocyte reaction (MLR). Treatment of PBL with 4-hydroperoxycyclophosphamide (4-HPCy) before incubation with ConA markedly decreased the generation of suppressor cells by ConA. The effect of 4-HPCy on generation of suppressor cells was more pronounced in the test of ConA stimulation than in the MLR. Treatment with 4-HPCy had no effect on suppressor cells already induced as shown by incubation of PBL with 4-HPCy after incubation with ConA. |
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