The structure of an endosomal protein sorter |
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| Authors: | Slagsvold Thomas Stenmark Harald |
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| Affiliation: | Department of Biochemistry, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway. |
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| Abstract: | Three "endosomal sorting complexes required for transport," ESCRT-I, -II, and -III, mediate sorting of ubiquitinated membrane proteins into intraluminal endosomal vesicles that are destined for degradation in lysosomes. Two recent reports, one in Nature and one in this issue of Developmental Cell, reveal the crystal structure of the yeast form of ESCRT-II. |
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