Modulators of the eukaryotic heat shock response |
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| Authors: | K W Lanks |
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| Affiliation: | 1. College of Life Sciences and Bioengineering, Beijing Jiaotong University, 100044, Beijing, People’s Republic of China;2. Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA; National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, 100193, Beijing, People’s Republic of China;3. Department of Animal Sciences, Purdue University, 47907, West Lafayette, IN, USA;4. Xiertala Cattle Breeding Farm, Hailaer Farm Buro, 021012, Hailaer, Inner Mongolia, People’s Republic of China;5. Moguai Farm, Hailaer Farm Buro, 022150, Hailaer, Inner Mongolia, People’s Republic of China;1. US Meat Animal Research Center, ARS, USDA, Clay Center, NE 68933;2. Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX 79409;3. College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506;4. Department of Agricultural Sciences, West Texas A&M University, Canyon, TX 79016;5. Livestock Issues Research Unit, ARS, USDA, Lubbock, TX 79403;1. Molecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, 250 001, Meerut, Uttar Pradesh, India;2. Sam Higginbottom University of Agriculture Technology and Science, Allahabad, India;3. School of Atmospheric Stress Management, National Institute of Abiotic Stress Management, Baramati, Maharashtra, India;4. Department of Animal Biotechnology, Anand Agricultural University, Anand, Gujarat, India;1. Molecular Genetics Laboratory, ICAR-Central Institute for Research on Cattle, -250 001, Meerut, Uttar Pradesh, India;2. Sam Higginbottom University of Agriculture Technology & Science, Allahabad, India;3. Department of Biotechnology, Center of Nanotechnology, Indian Institute of Technology, Roorkee, Uttarakhand, India;4. Center of Nanotechnology, Indian Institute of Technology, Roorkee, Uttarakhand, India;5. Ome Research Laboratory, Anand Agricultural University, Anand, Gujarat, India |
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| Abstract: | The nuclear lamina consists of a proteinaceous layer or meshwork situated subjacent to the inner nuclear membrane. It is a karyoskeletal structure formed by a polymer containing one to three major polypeptides collectively termed the lamins. In all cells examined of vertebrates and invertebrates, the lamins exhibit very similar Mr ranging from 60 000 to 80 000. In vertebrates, two groups of lamins can be distinguished by their isoelectric value, one being near-neutral and the other acidic (isoelectric pH values of 5.6 and lower). The lamins represent a family of polypeptides with regions highly conserved during evolution. In certain species, e.g., the amphibian, Xenopus laevis, they exhibit cell type-specific expression during embryonic development, terminal differentiation of certain somatic cells, and gametogenesis. The nuclear lamina of diverse cell types can be composed of one, two or three different lamin polypeptides, without obvious differences in its morphology. |
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