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Structure-directed discovery of an inhibitor of the binding of HIV GP120 to the CD4 receptor |
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| Authors: | Richard L Jarvest Ann L Breen Colin M Edge Margery A Chaikin L John Jennings Alemseged Truneh Raymond W Sweet and Robert P Hertzberg |
| Institution: | a SmithKline Pharmaceuticals Great Burgh, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, U.K. b SmithKline Beecham Pharmaceuticals King of Prussia, Pennsylvania 19406, USA |
| Abstract: | Structure-directed screening identified the diphenyl lactone (1) as a specific inhibitor of the interaction of HIV gp120 with CD4. The compound bound selectively to gp120 in a time-dependent and irreversible fashion. |
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