The first ferrocene analogues of muramyldipeptide |
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| Authors: | Barišić Lidija Roščić Maja Kovačević Monika Semenčić Mojca Čakić Horvat Stefica Rapić Vladimir |
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| Affiliation: | aDepartment of Organic Chemistry, Faculty of Food Technology and Biotechnology, Pierottijeva 6, HR-10000 Zagreb, Croatia;bDivision of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Bijeni?ka 54, HR-10000 Zagreb, Croatia |
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| Abstract: | The two structurally interesting bioorganometallic analogues of muramyldipeptide (MDP) with potential immunomodulatory activity were synthesized starting from the O-protected N-acetylmuramic acid (MurNAc), l- or d-Ala and 1′-aminoferrocene-1-carboxylic acid (Fca). They were fully characterized by IR, 1H NMR, 13C NMR and CD spectroscopy as well as by FD mass spectrometry. |
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| Keywords: | Ferrocene 1&prime -Aminoferrocene-1-carboxylic acid (Fca), Muramyldipeptide (MDP) β-Turn Intramolecular hydrogen bond (IHB) |
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