Amorphous trehalose dihydrate by cryogenic milling |
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Authors: | Megarry A J Booth J Burley J |
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Affiliation: | aSchool of Pharmacy, University of Nottingham, Boots Science Building, University Park, Nottingham NG7 2RD, UK;bAstraZeneca, Silk Road Business Park, Macclesfield, Cheshire SK10 2NA, UK |
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Abstract: | Trehalose dihydrate is a safe, naturally occurring disaccharide used as a food ingredient and pharmaceutical excipient. It has been reported that room temperature milling does not lead to the formation of amorphous trehalose dihydrate. This paper reports the behaviour of trehalose dihydrate upon milling at cryogenic temperatures as studied by DSC, TGA, XRPD and Raman spectroscopy. We have demonstrated that the crystal to glass transformation for trehalose dihydrate is possible using cryogenic milling. This is the first reported example of cryogenic milling (a mild and widely applicable technique) applied to generating amorphous hydrates. |
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Keywords: | Amorphous Hydrates Cryomilling XRPD DSC Raman spectroscopy |
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