The structure of the Escherichia coli O148 lipopolysaccharide core region and its linkage to the O-specific polysaccharide |
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| Authors: | Kubler-Kielb Joanna Lai Wen-Tzu Schneerson Rachel Vinogradov Evgeny |
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| Institution: | aNational Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA;bInstitute for Biological Sciences, National Research Council, 100 Sussex Dr., Ottawa, ON, Canada K1A 0R6 |
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| Abstract: | Recently it was demonstrated that Shigella dysenteriae type 1, a cause of severe dysentery epidemics, gained its O-specific polysaccharide (O-SP) from Escherichia coli O148. The O-SPs of these bacteria differ only by a galactose residue in the repeat unit of S. dysenteriae type 1 in place of a glucose residue in E. coli O148. Herein, we analyzed the core structure and its linkage to the O-SP in E. coli O148 LPS. Both were found to be identical to those of S. dysenteriae type 1 structures, further supporting the relatedness of these two bacteria. The following structure of the core with one repeat unit of the O-SP has been assigned (all have d-configuration except l-Rha): |
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| Keywords: | Escherichia coli O148 LPS O-Specific polysaccharide Core Structure |
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