Synthesis and NMR studies on the ABO histo-blood group antigens: synthesis of type III and IV structures and NMR characterization of type I-VI antigens |
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| Authors: | Meloncelli Peter J West Lori J Lowary Todd L |
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| Institution: | aDepartment of Chemistry and Alberta Ingenuity Centre for Carbohydrate Science, Gunning-Lemieux Chemistry Centre, University of Alberta, Edmonton, AB, Canada T6G 2G2;bFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2E1 |
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| Abstract: | The ABO histo-blood group antigens are best known for their important roles in solid organ and bone marrow transplantation as well as transfusion medicine. Here we report the synthesis of the ABO type III and IV antigens with a 7-octen-1-yl aglycone. Also described is an NMR study of the ABO type I to VI antigens, which were carried out to probe differences in overall conformation of the molecules. These NMR investigations showed very little difference in the 1H chemical shifts, as well as 1H–1H coupling constants, across all compounds, suggesting that these ABO subtypes adopt nearly identical conformations in solution. |
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| Keywords: | ABO histo-blood group ABO type III ABO type IV Chemical synthesis Trichloroacetimidate 7-Octen-1-yl |
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