Synthesis of mucin O-glycan core structures as their p-nitro- and p-aminophenyl glycosides |
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Authors: | Hollinger Martin Abraha Fana Oscarson Stefan |
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Institution: | Centre for Synthesis and Chemical Biology, UCD School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland |
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Abstract: | For the investigation of glycosidases, and for the construction of glycan arrays the p-nitrophenyl- and p-aminophenyl glycosides of mucin O-glycan core structures 1–7 and the 2,6-ST-antigen have been chemically synthesized using d-galactose as a precursor for GalNAc residues. GlcNAc residues have partly been introduced using a 4,6-di-O-benzoyl-2,3-N,O-oxazolidinone-protected donor, which allowed deprotection of the formed di- and tri-saccharides in one step using sodium methoxide. |
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Keywords: | Mucin O-glycan core structures Oxazolidinone protected glycosyl donors Oligosaccharide synthesis |
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