Synthesis, physicochemical and spectroscopic characterization of copper(II)-polysaccharide pullulan complexes by UV-vis, ATR-FTIR, and EPR |
| |
Authors: | Mitić Zarko Cakić Milorad Nikolić Goran M Nikolić Ružica Nikolić Goran S Pavlović Radmila Santaniello Enzo |
| |
Affiliation: | aDepartment of Pharmacy, Faculty of Medicine, University of Niš, RS-18000 Niš, Serbia;bFaculty of Technology, University of Niš, RS-16000 Leskovac, Serbia;cFaculty of Sciences and Mathematics, University of Niš, RS-18000 Niš, Serbia;dDepartment of Medicine, Surgery and Dentistry, University of Milan, Polo Universitario S. Paolo, I-20142 Milan, Italy |
| |
Abstract: | Bioactive copper(II) complexes with polysaccharides, like pullulan and dextran, are important in both veterinary and human medicine for the treatment of hypochromic microcitary anemia and hypocupremia. In aqueous alkaline solutions, Cu(II) ion forms complexes with the exopolysaccharide pullulan and its reduced low-molecular derivative. The metal content and the solution composition depend on pH, temperature, and time of the reaction. The complexing process begins in a weak alkali solution (pH >7) and involves OH groups of pullulan monomer (glucopyranose) units. Complexes of Cu(II) ion with reduced low-molecular pullulan (RLMP, Mw 6000 g mol−1) were synthesized in water solutions, at the boiling temperature and at different pH values ranging from 7.5 to 12. The Cu(II) complex formation with RLMP was analyzed by UV–vis spectrophotometry and other physicochemical methods. Spectroscopic characterizations (ATR-FTIR, FT-IRIS, and EPR) and spectra–structure correlation of Cu(II)–RLMP complexes were also carried out. |
| |
Keywords: | Complexes Cu(II) Pullulan UV&ndash vis ATR-FTIR EPR |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|