Aflatoxins: Detection,toxicity, and biosynthesis |
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Authors: | Jin Hanwan Do Dong-Kug Choi |
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Institution: | (1) Bio-food and Drug Research Center, Konkuk University, 380-701 Chungju, Korea;(2) Department of Biotechnology, Konkuk University, 380-701 Chungju, Korea |
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Abstract: | Aflatoxins are toxic and carcinogenic secondary metabolites produced mainly byAspergillus flavus andAspergillus parasiticus. The aflatoxins present in food and feed are hazardous to both human and animal health. A number of studies have been conducted
on the detection, toxicity, biosynthesis, and regulation of aflatoxins due to the discovery of serious aflatoxicosis in farm
animals, and the presence of aflatoxins in many food products. There are many reviews that focus on the biosynthesis of aflatoxin,
yet there are few examinations of the overall aspects of aflatoxins, including detection, toxicity, and the regulation on
biosynthesis. Thus, the goal of this article is to give an overview of the overall aspects of aflatoxins. This review consists
of four parts; i) detection methods for aflatoxins, ii) the toxicity mechanism of aflatoxin B1, iii) gene cluster for aflatoxin
biosynthesis, and iv) the regulation of aflatoxin biosynthesis. |
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Keywords: | aflatoxin fluorescence ELISA toxicity biosynthesis gene regulation |
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