Bacterial outer membrane proteins: topological analyses and biotechnological perspectives |
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Authors: | Stathopoulos C |
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Institution: | Washington University, Department of Biology, St. Louis, MO 63130, USA. cstatho@biodec.wustl.edu |
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Abstract: | The outer membrane proteins (OMPs) from gram-negative bacteria form a distinct group of integral membrane proteins with unusual primary, secondary and tertiary structures. Unlike typical prokaryotic and eukaryotic membrane proteins, bacterial OMPs contain primarily polar sequences, arranged in amphipathic antiparallel beta-barrels, and inclined to the plane of the membrane. Due to their unique structure, OMPs have recently become the subject of extensive study. This article reviews (i) experimental and theoretical approaches of topological analyses used in the study of OMPs, and (ii) the applications of OMPs. |
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