Correlation of T cell independence of antibody responses with antigen dose reaching secondary lymphoid organs: implications for splenectomized patients and vaccine design |
| |
Authors: | Ochsenbein A F Pinschewer D D Odermatt B Ciurea A Hengartner H Zinkernagel R M |
| |
Institution: | Institute for Experimental Immunology, University Hospital, Zurich, Switzerland. adrian.ochsenbein@insel.ch |
| |
Abstract: | Many natural viral and bacterial pathogens activate B cells independently of Th cells (TI Ags). This study analyzed the characteristics of the activation of B cells after immunization with various forms of viral Ags using different immunization routes and found a decreasing dependence on T help with increasing amounts of Ag recruited to the spleen. Repetitive antigenic structure facilitated TI B cell responses if Ag was present in lymphoid organs. These results suggest that 1) Ag dose and localization in secondary lymphoid organs are the key for B cell activation in the absence of T help; 2) early TI Ab responses are crucial to protect against systemically spreading acute cytopathic infectious agents; and 3) there may be new rationales for improved vaccine design. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |