(cis)-3-methyl-1,5-benzothiazepine-4-ones: potent analogs of the calcium channel blocker diltiazen |
| |
| Authors: | Karnail S. Atwal Syed Z. Ahmed David M. Floyd Suzanne Moreland Anders Hedberg |
| |
| Affiliation: | Bristol-Myers Squibb Pharmaceutical Research Institute, P. O. Box 4000, Princeton, N.J. 08543 U.S.A. |
| |
| Abstract: | 3-Methyl analogs of the calcium channel blocker diltiazem are reported. The title compounds were prepared from readily available amino thiophenols by a six step sequence which involves setting up the desired 2,3-cis-stereochemistry through decarboxylation under acidic conditions. To our knowledge, there are the most potent analogs of diltiazem reported to date. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
