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New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity |
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| Authors: | Normand-Bayle Marie Bénard Christophe Zouhiri Fatima Mouscadet Jean-François Leh Hervé Thomas Claire-Marie Mbemba Gladys Desmaële Didier d'Angelo Jean |
| Affiliation: | Unité Associée au CNRS, UMR 8076, Faculté de Pharmacie, 5, rue J.-B. Clément, 92290 Chatenay-Malabry, France. |
| Abstract: | Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays. |
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