人参皂甙Re对神经内分泌系统功能的影响

研究人参皂甙Re对神经内分泌系统的保护作用。采用高效液相色谱检测法测定水浸．束缚应激大鼠脑内单胺类递质和血清皮质酮的含量。水浸-束缚应激模型能使大鼠额叶、纹状体、下丘脑三个脑区的单胺类递质及其代谢产物（去甲肾上腺素、多巴胺、高香草酸、5-羟色胺、5．羟吲哚乙酸）和血清皮质酮的含量明显增高。预先给予人参皂甙Re（4．5和9mg／kg，ig）后均有不同程度的降低，并呈一定的量效关系。结果表明人参皂甙Re具有一定的神经保护作用。

Effects of Ginsenoside Re on the Levels of Brain Monoamines Transmitters and Serum Corticosterone in Water Immersion-restraint Rats

To investigate the effect of ginsenoside Re on the function of the neuroendocrine system,in water immersion-restraint rats,the contents of brain monoamines transmitters and serum corticosterone were evaluated using high performance liquid chromatography. There was a significant increase of content of brain monoamines transmitters and their metabolites, noradrenaline(NA) , dopamine( DA) , 5-hydroxytryptamine (5-HT) , homovanillic acid( HVA) , 5-hydroxyin-dole-3-acetic acid(5-HIAA) ,and serum corticosterone in pallium,striatum.hypothalamus of water immersion-restraint rats. The elevated level was markedly and dose-dependently reduced by ginsenoside Re(3,6 and 9 mg · kg~(-1)). The data indicated that ginsenoside Re possesses significant effect of recovering the marked increase of neurotransmitters induced by water immersion-restraint stress. This study demonstrates the neuroprotective potential of ginsenoside Re in water immersion-restraint rats.