Long noncoding RNA HAND2-AS1 inhibits cancer cell proliferation,migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA-21 |
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| Authors: | Yusheng Yan Shaobin Li Suihai Wang Pietro Rubegni Linda Tognetti Jiaqing Zhang Lu Yan |
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| Affiliation: | 1. Department of Cardiothoracic Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China;2. School of Biotechnology, Southern Medical University, Guangzhou, China;3. Department of Medical, Surgical and Neuro Sciences, Section of Dermatology, University of Siena, Siena, Italy;4. Department of Dermatology, Zhujiang Hospital of Southern Medical University, Guangzhou, China |
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| Abstract: | Long noncoding RNA (lncRNA) HAND2-AS1 is a well-characterized tumor suppressor in several types of malignancies, while its role in esophagus squamous cell carcinoma (ESCC) is unknown. In this study, we found that lncRNA HAND2-AS1 was downregulated, while microRNA-21 ( miRNA-21) was upregulated in tumor tissues than in adjacent healthy tissues of ESCC patients. Expression levels of lncRNA HAND2-AS1 and miRNA-21 were significantly and inversely correlated in tumor tissues but not in healthy tissues. Plasma levels of lncRNA HAND2-AS1 were lower in ESCC patients than in healthy controls, and downregulation of plasma lncRNA HAND2-AS1 distinguished early stage ESCC patients from healthy controls. lncRNA HAND2-AS1 overexpression resulted in downregulation of miRNA-21 in cells of ESCC cell lines and inhibited cell proliferation, migration, and invasion. miRNA-21 overexpression failed to affect lncRNA HAND2-AS1 expression but significantly attenuated the inhibitory effect of lncRNA HAND2-AS1 overexpression on cancer cell proliferation, migration, and invasion. Therefore, lncRNA HAND2-AS1 may inhibit cancer cell proliferation, migration, and invasion in ESCC by regulating miRNA-21. |
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| Keywords: | esophagus squamous cell carcinoma invasion lncRNA HAND2-AS1 migration miRNA-21 proliferation |
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