Regulation effects of melatonin on bone marrow mesenchymal stem cell differentiation |
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Authors: | Biao Wang Hao Wen Wanli Smith Dingjun Hao Baorong He Lingbo Kong |
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Affiliation: | 1. Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an, China Biao Wang and Hao Wen have contributed equally to this work.;2. Department of Orthopedic, Yan’an University Medical School, Yan’an, China Biao Wang and Hao Wen have contributed equally to this work.;3. Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland;4. Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Xi’an, China |
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Abstract: | Melatonin’s therapeutic potential has been highly underestimated because its biological functional roles are diverse and relevant mechanisms are complicated. Among the numerous biological activities of melatonin, its regulatory effects on pluripotent mesenchymal stem cells (MSCs), which are found in bone marrow stem cells (BMSCs) and adipose tissue (AD-MSC), have been recently proposed, which has received increasingly more attention in recent studies. Moreover, receptor-dependent and receptor-independent responses to melatonin are identified to occur in these cells by regulating signaling pathways, which drive the commitment and differentiation of MSCs into osteogenic, chondrogenic, or adipogenic lineages. Therefore, the aim of our current review is to summarize the evidence related to the utility of melatonin as a regulatory agent by focusing on its relationship with the differentiation of MSCs. In particular, we aimed to review its roles in promoting osteogenic and chondrogenic differentiation and the relevant signaling cascades involved. Also, the roles that melatonin and, particularly, its receptors play in these processes are highlighted. |
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Keywords: | BMSCs melatonin signaling pathways stem cell |
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