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Angiotensin-converting enzyme insertion/deletion (rs106180) and angiotensin type 1 receptor A1166C (rs106165) genotypes and psoriasis: Correlation with cellular immunity,lipid profile,and oxidative stress markers
Authors:Maryam Tanhapour  Badieh Falahi  Asad Vaisi-Raygani  Fariborz Bahrehmand  Amir Kiani  Zohreh Rahimi  Ali-Akbar Vaisi-Raygani  Ebrahim Shakiba  Tayebeh Pourmotabbed
Institution:1. Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Tissue Engineering and Regenerative Medicine (TERM) Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran;4. Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran;5. Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee
Abstract:Psoriasis is a chronic inflammatory skin condition and angiotensin-converting enzyme (ACE) is a key circulating enzyme converting angiotensin (Ang) I to the vasoactive peptide Ang II. The exact role of ACE insertion (I)/deletion (D) polymorphism (rs106180) in psoriasis is not clear. We aimed to examine whether the ACE I/D and Ang II type 1 receptor (AT1R) A1166C-polymorphisms (rs106165), lipid profile, and stress oxidative are associated with susceptibility to psoriasis. One hundred patients with psoriasis and 100 sex- and age-matched unrelated healthy controls were recruited for this case-control study. ACE I/D and AT1R A1166C polymorphisms were identified by the polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively, malondialdehyde (MDA) was detected by the high-performance liquid chromatography, serum arylesterase (ARE) activity of paraoxonase and catalase activities were detected by the spectrophotometry, superoxide dismutase (SOD) activity and vascular adhesion protein (VAP)-1 were measured by ELISA. The presence of C allele of AT1R A1166C and I allele of ACE considerably increased the risk of psoriasis by 6.42-fold (P < 0.001). The distribution of II-genotype of ACE was significantly higher in psoriasis patients than in control group and increased the risk of disease by 3.11-times (P = 0.023). The higher levels of MDA in patients and the higher activity of SOD, ARE, and CAT was observed in healthy controls with I/D+I/I-genotype of ACE I/D. This study for the first time demonstrated that the ACE I/D and AT1R A 1166C genes polymorphisms robustly increases the risk of developing psoriasis in population from west of Iran. In addition, these individuals had significantly higher VAP-1 and MDA concentration and lower enzymatic and nonenzymatic antioxidant-status, suggesting that psoriatic patients carrying C allele of AT1R1166 polymorphism may be more susceptible to cardiovascular disease and myocardial infarction compared with A allele.
Keywords:angiotensin-converting enzyme (ACE) I/D genotypes  Ang II type 1 receptor (AGTR1) A1166C variants  arylesterase (ARE) activity of paraoxonase (PON)  catalase  lipid and lipoprotein profiles  malondialdehyde (MDA)  psoriasis  vascular adhesion protein-1 (VAP-1)
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