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Engineered zinc-finger nuclease to generate site-directed modification in the KLF1 gene for fetal hemoglobin induction |
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| Authors: | Laleh Shariati Mohammad Hossein Modarressi Mohammad Amin Tabatabaiefar Shirin Kouhpayeh Zahra Hejazi Mansoureh Shahbazi Faezeh Sabzehei Mansoor Salehi Hossein Khanahmad |
| Institution: | 1. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran;4. Department of Immunology, Erythron Genetics and Pathobiology Laboratory, Isfahan, Iran;5. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |
| Abstract: | |
| Keywords: | hereditary persistence of HbF integrase minus lentivirus KLF1 zinc-finger nuclease γ-globin |