|
|||||
|
|
Reactive oxygen species in colorectal cancer: The therapeutic impact and its potential roles in tumor progression via perturbation of cellular and physiological dysregulated pathways |
|
| Authors: | Reyhaneh Moradi-Marjaneh Seyed Mahdi Hassanian Mehraneh Mehramiz Majid Rezayi Gordon A Ferns Majid Khazaei Amir Avan |
| Institution: | 1. Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran
Department of Physiology and Neurogenic inflammation research center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;4. Brighton & Sussex Medical School, Division of Medical Education, Brighton, UK |
| Abstract: | Reactive oxygen species (ROS) are produced by mitochondria during metabolism. In physiological states, the production of ROS and their elimination by antioxidants are kept in balance. However, in pathological states, elevated levels of ROS interact with susceptible cellular target compounds including lipids, proteins, and DNA and deregulate oncogenic signaling pathways that are involved in colorectal cancer (CRC) carcinogenesis. Although antioxidant compounds have been successfully used in the treatment of CRC as prevention approaches, they have also been shown in some cases to promote disease progression. In this review, we focus on the role of ROS in gastrointestinal homeostasis, CRC progression, diagnosis, and therapy with particular emphasis on ROS-stimulated pathways. |
| Keywords: | antioxidants colorectal cancer progression reactive oxygen species |