LncRNA OIP5-AS1 predicts poor prognosis and regulates cell proliferation and apoptosis in bladder cancer |
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| Authors: | Yang Wang Fu Shi Yong Xia Huacai Zhao |
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| Institution: | 1. Department of Urology, Hanzhong Central Hospital, Hangzhong, China;2. Department of Urology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China;3. Department of Urology, The Third Affiliated Hospital of Xi’an Jiaotong University, Shaanxi Provincial People’s Hospital, Xi’an, China |
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| Abstract: | Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) is a long intergenic noncoding RNA, which has been suggested to be dysregulated in human cancers and served as tumor suppressor or promoter depending on tumor types. However, the role of OIP5-AS1 in bladder cancer was still unknown. In our study, OIP5-AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. The loss-of-function studies suggested downregulation of OIP5-AS1 expression decreased cell viability, induced cell-cycle arrest and promoted cell apoptosis in bladder cancer. There was a positive association between OIP5-AS1 expression and OIP5 expression in bladder cancer tissues. Moreover, downregulation of OIP5-AS1 expression reduced messenger RNA and protein levels of OIP5 in bladder cancer cell lines. In conclusion, OIP5-AS1 is a useful biomarker for predicting clinical progression and poor prognosis and promotes cell proliferation through modulating OIP5 expression. |
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| Keywords: | biomarker bladder cancer long noncoding RNA Opa-interacting protein 5 antisense RNA 1 Opa-interacting protein 5 |
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