Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective |
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| Authors: | Mehran Pashirzad Mojtaba Shafiee Amir Avan Mikhail Ryzhikov Hamid Fiuji Amirhossein Bahreyni Majid Khazaei Saman Soleimanpour Seyed Mahdi Hassanian |
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| Affiliation: | 1. Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;4. Division of Pulmonary and Critical Care Medicine, Washington University, School of Medicine, Saint Louis, Missouri;5. Department of Biochemistry, Payame-Noor University, Mashhad, Iran;6. Department of Clinical Biochemistry and Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran;7. Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;8. Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti-inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti-inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti-inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases. |
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| Keywords: | crocin inflammatory diseases saffron |
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