Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway |
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| Authors: | Peigang Ji Liang Wang Jinghui Liu Ping Mao Ruichun Li Haitao Jiang Miao Lou Meng Xu Xiao Yu |
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| Affiliation: | 1. Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China;2. Department of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China |
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| Abstract: | Ribosomal protein L34 (RPL34), belonging to the L34E family of ribosomal proteins, was reported to be dysregulated in several types of cancers and plays important roles in tumor progression. However, the expression and roles of RPL34 in human glioma remain largely unknown. Thus, the objective of this study was to investigate the expression and role of RPL34 in glioma. We report here that RPL34 is highly expressed in human glioma tissues and cell lines. Knockdown of RPL34 markedly inhibited the proliferation, migration, and invasion, as well as prevented the epithelial-mesenchymal transition phenotype in glioma cells. Further, mechanistic analysis showed that knockdown of RPL34 significantly downregulated the levels of p-JAK and p-STAT3 in glioma cells. Taken together, our findings indicated that knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway. Thus, RPL34 may serve as a potential therapeutic target for the treatment of glioma. |
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| Keywords: | glioma migration proliferation ribosomal protein L34 |
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