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Roles of phosphatase and tensin homolog in skeletal muscle |
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| Authors: | Tizhong Shan Jiaqi Liu Ziye Xu Yizhen Wang |
| Affiliation: | 1. Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, China;2. Institute of Feed Science, College of Animal Sciences, Zhejiang University, Hangzhou, China The Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Hangzhou, China Zhejiang Provincial Laboratory of Feed and Animal Nutrition, Hangzhou, China |
| Abstract: | The phosphatase and tensin homolog (PTEN), originally identified as a tumor suppressor, is an important regulator of the PI3K–Akt pathway. PTEN plays crucial roles in various cellular processes, including cell survival, cell growth, cell proliferation, cell differentiation, and cell metabolism. In metabolic tissues, PTEN expression affects insulin sensitivity and glucose homeostasis. In skeletal muscle, the deletion of PTEN regulates muscle development and protects the mutant mice from insulin resistance and diabetes. Notably, the regulatory role of PTEN in skeletal muscle stem cells has been recently reported. In this review, we mainly discuss the role of PTEN in regulating the development, glucose metabolism, stem cell fate decision, and regeneration of skeletal muscle. |
| Keywords: | PTEN regeneration satellite cell skeletal muscle stem cell |