Dysregulation of microRNA-657 influences inflammatory response via targeting interleukin-37 in gestational diabetes mellitus |
| |
| Authors: | Pingping Wang Haidong Wang Cuihong Li Xiaozhen Zhang Xia Xiu Ping Teng Zengfang Wang |
| |
| Institution: | 1. Department of Gynecology and Obstetrics, Weifang Hospital of Maternal and Child Health, Weifang, China;2. Department of Obstetrics, The Affiliated Huai’an First Hospital of Nanjing Medical University, Huai’an, China;3. Department of Gynaecology and Obstetrics, Yidu Central Hospital of Weifang, Weifang, China;4. Library of Weifang Medical University, Weifang, China |
| |
| Abstract: | A number of studies have implicated that microRNAs (miRNAs) play a critical role in the development of gestational diabetes mellitus (GDM). However, the role of miR-657 in GDM remains vague up to date. We aim to investigate the modifying effect of miR-657 on GDM, which will provide new insight into the pathogenesis of GDM and may help to identify new diagnostic or therapeutic targets for GDM. Increased expression of miR-657 but decreased expression of interleukin-37 (IL-37) was observed in patients with GDM. Besides, negative association between miR-657 and IL-37 was demonstrated in this study. miR-657 could targetedly regulate IL-37 and enhance the proliferation of mononuclear macrophages. Moreover, miR-657 promoted the generation of inflammatory cytokines (IL-6 and tumor necrosis factor-α TNF-α]) and activation of nuclear factor κB (NF-κB) in lipopolysaccharide-induced mononuclear macrophages, while its effect was significantly inhibited when exogenous recombinant IL-37 was administrated into cells. Accordingly, dysregulation of miR-657 contributes to the pathogenesis of GDM via IL-37/NF-κB signaling axis. |
| |
| Keywords: | gestational diabetes mellitus IL-37 inflammation microRNA NF-κB |
|
|
