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Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression
Authors:Bai Yuquan MD  Tang Hexiao MD  PhD  Wan Laiyi MD  Pan Gaofeng MD  PhD  Zhou Xuefeng MD  PhD  Xu Ming MD  PhD  Wei Yanhong MD  PhD  Zhang Li MD  PhD  Zhao Jinping MD  PhD
Institution:1. Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Donghu Road, Wuhan, China

Bai Yuquan and Tang Hexiao have contributed equally to this study.;2. Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Donghu Road, Wuhan, China;3. Department of Nephrology, Wuhan Central Hospital, Tongji Medical College, Huazhong University of Science and Technology, Shengli Street, Wuhan, China

Abstract:Even though the interaction between epithelial growth factor receptor (EGFR) and interleukin-6 receptor (IL-6R) has been found in many tumors, there is a lack of relevant in-depth study of lung cancer. The following study investigates the interaction of EGFR and IL-6R in lung cancer. In the current study, EGFR, IL-6, and glycoprotein 130 (GP130) were highly expressed in non–small cell lung cancer (NSCLC) tissue samples and were associated with clinicopathological features and poor prognosis of patients with NSCLC. Furthermore, the effect of EGF and IL-6 on biological behavior of lung cancer cells (cell proliferation, invasion, cycle, and apoptosis) and the expression of EGFR, GP130, p-protein kinase B (p-AKT), and p-p44/42 mitogen-activated protein kinase (p-p44/42 MAPK) was significantly stronger compared with other treatment groups (all P < 0.05). These results suggest that EGFR and IL-6R have synergistic effects on NSCLC progression. This could help to solve the problem of EGFR inhibitors in the treatment of lung cancer resistance and improve the efficacy of current treatment for lung cancer through a combination of EGFR and IL-6R signaling pathways.
Keywords:epithelial growth factor receptor (EGFR)  glycoprotein 130 (GP130)  non–small cell lung cancer (NSCLC)  tissue microarray-immunohistochemistry
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