Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise |
| |
| Authors: | Helena Angelica Pereira Batatinha Tiego Aparecido Diniz Alexandre Abilio de Souza Teixeira Karsten Krüger Jose Cesar Rosa-Neto |
| |
| Affiliation: | 1. Department of Cell and Developmental Biology, University of São Paulo, São Paulo, São Paulo, Brazil;2. Department Exercise and Health, Institute of Sports Science, Leibniz University Hannover, Hannover, Germany |
| |
| Abstract: | Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration. |
| |
| Keywords: | autophagy cancer exercise immunosenescence neurodegeneration |
|
|
