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Disruption of the redox balance with either oxidative or anti-oxidative overloading as a promising target for cancer therapy |
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| Authors: | Bagher Farhood Masoud Najafi Eniseh Salehi Nasser Hashemi Goradel Maryam Shabani Nashtaei Neda Khanlarkhani Keywan Mortezaee |
| Affiliation: | 1. Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran;2. Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Infertility Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran;6. Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran |
| Abstract: | Oxidative stress acts as a double-edged sword by being both a promoter and a suppressor of cancer. Moderate oxidative stress is beneficial for cancer cell proliferative and invasiveness features, while overexposure of the cells to oxidative insults could induce cancer cell apoptosis and reduce hypoxia along with modulating the immune system for regression of tumor. Cancer cells and cancer stem cells have highly efficient redox systems that make them resistant to oxidative insults. The redox disruptive approach is an area of current research and key for oxidative targeted cancer therapies. This disruption is applicable by using either oxidative or anti-oxidative overloading strategies, specifically on cancer cells without influencing normal cells or tissues around tumor. The activity of tumor suppressor cells within tumor microenvironment is needed to be maintained in patients receiving such approaches. |
| Keywords: | cancer oxidative stress reactive oxygen species (ROS) redox |