Role of miR-142 in the pathogenesis of osteosarcoma and its potential as therapeutic approach |
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Authors: | Parastoo Shabani Sama Izadpanah Ali Aghebati-Maleki Elham Baghbani Amir Baghbanzadeh Ali Fotouhi Babak Bakhshinejad Leili Aghebati-Maleki Behzad Baradaran |
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Affiliation: | 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran Department of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;3. Department of Orthopedic Surgery, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan |
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Abstract: | Osteosarcoma (OS) is the most common primary malignant tumor of the bone with a strong tendency to early metastasis, and occurs in growing bones more commonly in children and adolescents. Considering the limited therapeutic methods and lack of 100% success of these methods, developing innovative therapies with high efficacy and lower side effects is needed. Meanwhile, miRNAs and the studies indicating the involvement of miRNAs in OS development have attracted attentions as a result of the frequent abnormalities in expression of miRNAs in cancer. miRNAs are noncoding short sequences with lengths ranging from 18 to 25 nucleotides that play a very important role in cellular processes, such as proliferation, differentiation, migration, and apoptosis. MiRNAs can have either oncogenic or tumor suppressive role based on cellular function and targets. This review aimed to have overview on miR-142 as a tumor suppressor in OS. Moreover, the genes involved in the disease, such as RAC1, HMAG1, MMP9, MMP2, and E-cadherin, which have irregularities as a result of change in miR-142 expression, and, thereby, result in increasing the proliferation, invasion, and metastasis of the cells in the tissues and OS cells will be discussed. |
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Keywords: | cancer therapy microRNA-142 osteosarcoma |
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