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The role of microRNAs in 5-FU resistance of colorectal cancer: Possible mechanisms |
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| Authors: | Reyhaneh Moradi Marjaneh Majid Khazaei Gordon A Ferns Amir Avan Seyed Hamid Aghaee-Bakhtiari |
| Institution: | 1. Torbat Heydarieh University of Medical Sciences, Torbat Heydarieh, Iran
Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Reyhaneh Moradi Marjaneh and Majid Khazaei have contributed equally to this work as joint first author.;2. Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Medical Education, Brighton and Sussex Medical School, Perso Falmer, Brighton, UK;4. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | Colorectal cancer (CRC) is one of the most common cancers globally. Despite recent advances in therapeutic approaches, this cancer continues to have a poor prognosis, particularly when diagnosed late. 5-Fluorouracil (5-FU) has been commonly prescribed for patients with CRC, but resistance to 5-FU is one of the main reasons for failure in the treatment of this condition. Recently, microRNAs (miRNAs) have been established as a means of modifying the signaling pathways involved in initiation and progression of CRC and their role as oncogene or tumor suppressor have been investigated in various studies. Moreover, miRNAs through various mechanisms play an important role in inducing tumor resistance or sensitivity to anticancer drugs. Detecting and targeting these mechanisms may be a new therapeutic approach. This review summarizes the current knowledge about the potential roles of miRNAs in 5-FU resistance, with particular emphasis on molecular mechanism involved. |
| Keywords: | 5-FU resistance colorectal cancer microRNA |