Immunoresolvents in asthma and allergic diseases: Review and update |
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| Authors: | Ramin Lotfi Alireza Rezaiemanesh Seyed Hamidreza Mortazavi Ali Gorgin Karaji Farhad Salari |
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| Institution: | 1. Student Research Committee, Department of immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran |
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| Abstract: | Asthma and allergic diseases are inflammatory conditions developed by excessive reaction of the immune system against normally harmless environmental substances. Although acute inflammation is necessary to eradicate the damaging agents, shifting to chronic inflammation can be potentially detrimental. Essential fatty-acids-derived immunoresolvents, namely, lipoxins, resolvins, protectins, and maresins, are anti-inflammatory compounds that are believed to have protective and beneficial effects in inflammatory disorders, including asthma and allergies. Accordingly, impaired biosynthesis and defective production of immunoresolvents could be involved in the development of chronic inflammation. In this review, recent evidence on the anti-inflam]matory effects of immunoresolvents, their enzymatic biosynthesis routes, as well as their receptors are discussed. |
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| Keywords: | Allergy asthma immunoresolvents inflammation |
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