Chitosan-based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects |
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| Authors: | Mahsa Saheb Narges Fereydouni Saeideh Nemati George E Barreto Thomas P Johnston Amirhossein Sahebkar |
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| Institution: | 1. Department of Basic Science, Islamic Azad University of Damghan, Damghan, Iran;2. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C, Colombia;4. Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, Missouri;5. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin. |
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| Keywords: | bioavailability chitosan curcumin drug delivery solubility |
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