Comprehensive treatments for hepatocellular carcinoma with portal vein tumor thrombosis |
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| Authors: | Jin-Cheng Wang An-Liang Xia Yong Xu Xiao-Jie Lu |
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| Affiliation: | 1. Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Jin-Cheng Wang and An-Liang Xia have contributed equally to this study.;2. Department of Nephrology, Huai’an Second People’ Hospital and The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu, China;3. Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China |
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| Abstract: | Portal vein tumor thrombosis (PVTT) is one of the most common complications in hepatocellular carcinoma (HCC). HCC with PVTT usually indicates poor prognosis, which has a number of characteristics including a rapidly progressive disease course, worse liver function, complications connected with portal hypertension, and poorer tolerance to treatment. The exact mechanisms of PVTT remain unknown, even though some concerned signal transduction or molecular pathways have been identified. In western countries, sorafenib is the only recommended therapeutic strategy regardless of PVTT types. However, multiple treatment options including transhepatic arterial chemoembolization, hepatectomy, radiotherapy, and sorafenib available in the clinic. In this review, we enumerate and discuss therapeutics against patients with HCC having PVTT available in the clinic and put forward directions for future research. |
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| Keywords: | hepatectomy hepatocellular carcinoma (HCC) portal vein tumor thrombosis radiotherapy sorafenib transhepatic arterial chemoembolization |
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