lncRNA FLVCR1-AS1 silencing inhibits lung cancer cell proliferation,migration, and invasion by inhibiting the activity of the Wnt/β-catenin signaling pathway |
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| Authors: | Heping Lin Zongxiao Shangguan Mengchu Zhu Lianmin Bao Qing Zhang Shenghua Pan |
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| Institution: | 1. Department of Respiratory Diseases, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;2. Department of Clinical Laboratory, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;3. Department of Pathology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China |
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| Abstract: | Long noncoding RNAs have been reported to be essential regulators in several human diseases, including tumorigenesis. A recent report revealed that FLVCR1-AS1 promotes the progression of hepatocellular carcinoma. However, whether FLVCR1-AS1 is involved in lung cancer remains unclear. In this study, we found that the expression of FLVCR1-AS1 was increased in lung cancer tissues according to The Cancer Genome Atlas database. Similarly, FLVCR1-AS1 was significantly upregulated in lung cancer cell lines. Knockdown of FLVCR1-AS1 dramatically reduced the cell proliferation, migration, and invasion of SPCA1 and A549. Mechanistically, we found that the expression levels of CTNNB1, SOX4, CCND1, CCND2, c-MYC, as well as nucleus β-catenin were decreased in lung cancer cells after FLVCR1-AS1 silencing. Thus, FLVCR1-AS1 positively regulates the activation of the Wnt/β-catenin pathway. Overexpression of CTNNB1 reversed the effect of FLVCR1-AS1 knockdown on A549 cells. In sum, FLVCR1-AS1 silencing inhibited the proliferation, migration, and invasion of lung cancer cells by inhibiting the activity of the Wnt/β-catenin signaling pathway. |
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| Keywords: | FLVCR1-AS1 invasion lung cancer migration proliferation Wnt/β-catenin |
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