The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA-342-3p target sequence |
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| Authors: | Peng-Fei Zhang Jing Wu Yin Wu Wei Huang Min Liu Zhao-Ru Dong Bai-Ying Xu Yong Jin Fei Wang Xue-Mei Zhang |
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| Institution: | 1. Department of Oncology, Tongji University School of Medicine Affiliated Shanghai East Hospital, Shanghai, China;2. Department of General Surgery, Qilu Hospital, Shandong University, Jinan, China;3. Department of General Surgery, Xuhui District Central Hospital of Shanghai, Shanghai, China;4. Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China |
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| Abstract: | Long noncoding RNAs (lncRNAs) have been implicated in numerous physiological and pathological processes, including cancer development and progression. However, the role and molecular mechanism of lncRNAs in resistance to chemotherapy of colorectal cancer (CRC) remain enigmatic. Here, we found that lncRNA small Cajal body-specific RNA 2 (SCARNA2) is expressed higher in CRC tissues than in adjacent normal tissues, and a robust expression of SCARNA2 is correlated with a bad prognosis of CRC patients after surgery. SCARNA2 overexpression significantly promoted chemoresistance in CRC cells, and downregulation of SCARNA2 obviously inhibited chemoresistance in vitro. SCARNA2 promotes chemotherapy resistance via competitively binding miR-342-3p to facilitate epidermal growth factor receptor (EGFR) and B-cell lymphoma 2 (BCL2) expression in CRC cells. Together, our results reveal a novel pathway that SCARNA2 regulates CRC chemoresistance through targeting miR-342-3p-EGFR/BCL2 pathway, providing a promising therapeutic target for CRC. |
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| Keywords: | chemoresistance CRC lncRNA microRNA SCARNA2 |
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