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Diagnostic,prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer,current status and prospective |
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| Authors: | Amirhossein Bahreyni Melika Rezaei Afsane Bahrami Majid Khazaei Hamid Fiuji Mikhail Ryzhikov Gordon A Ferns Amir Avan Seyed Mahdi Hassanian |
| Institution: | 1. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
These authors contributed equally to this study.;2. Department of Biology, Ferdowsi University of Mashhad, Mashhad, Iran These authors contributed equally to this study.;3. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran;4. Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;5. Department of Biochemistry, Payame-Noor University, Mashhad, Iran;6. Division of Pulmonary and Critical Care Medicine, Washington University, School of Medicine, Saint Louis, Missouri;7. Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex, UK;8. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
| Abstract: | Aberrant microRNA (miR) expression is implicated in multiple human malignancies. miR-21, acting as a proto-oncogene, is involved in a variety of cellular processes and tumorigenesis and is frequently overexpressed in some cancer types. Several tumor suppressors, metastatic, and apoptotic genes have been identified as miR-21 targets, including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell death 4, Integrin-β4, and E-cadherin thereby regulating tumor growth, invasion, and metastasis. There is a growing evidence that miR-21 expression is associated with clinical outcomes in patients with colorectal cancer (CRC). In this review, we summarize the potential diagnostic, prognostic, and therapeutic values of miR-21 in CRC progression for a better understanding and hence a better management of this disease. |
| Keywords: | cancer outcome colorectal cancer Mir-21 |