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Deguelin inhibits RANKL-induced osteoclastogenesis in vitro and prevents inflammation-mediated bone loss in vivo
Authors:Tan Zhang  Kangxian Zhao  Weiqi Han  Wanlei Yang  Xuanyuan Lu  Qian Liu  Xiucheng Li  Yu Qian
Affiliation:1. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China;2. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;3. Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang, China;4. Orthopaedic Department, Research Centre for Regenerative Medicine, 5. The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

Abstract:
Keywords:deguelin  nuclear factor-κB (NF-κB)  osteoclast  osteoclastogenesis  therapeutics
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