| Institution: | 1. Labafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Medical Genetics, Medical Genetics Research Center, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Medical Genetics, Medical Genetics Research Center, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;4. School of Medicine, Iran University of Medical Sciences, Tehran, Iran;5. Faculty of Medicine, Islamic Azad University of Najafabad, Najafabad, Iran;6. Shohada Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;7. Department of Internal Medicine, Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
| Abstract: | Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis. Increasing evidence indicated that cellular and molecular alterations play critical roles in the initiation and progression of RA. Among various targets and molecular signaling pathways, microRNAs (miRNAs) and their regulatory networks have key roles in the RA pathogenesis. It has been showed that deregulation of many miRNAs involved in different stages of RA. Hence, identification of miRNAs and their signaling pathways in RA, could contribute to new knowledge which help to better treatment of patients with RA. Besides miRNAs, exosomes have been emerged as key messengers in RA pathogenesis. Exsosomes are nanocarriers which could be released from various cells and lead to changing of behaviors recipient cells via targeting their cargos (eg, proteins, messenger RNAs, miRNAs, long noncoding RNAs, DNAs). Here, we summarized several miRNAs involved in RA pathogenesis. Moreover, we highlighted the roles of exosomes in RA pathogenesis. |
